成功大學-中草藥新要暨健康食品研究中心單位網站

歡迎光臨成功大學-中草藥新要暨健康食品研究中心網站

主持人簡介

中心成員
中心主任
張智仁 教授
l   中國醫藥學院醫學士
l   現任國立成功大學醫學院醫學系家庭醫學科教授
l   現任中草藥新藥暨健康食品研究中心主任
 
(1) 學術專長:肥胖醫學、新陳代謝、家庭醫學、流行病學、老年醫學。
 
(2) 研究專長:
    長期從事糖尿病、肥胖症、高血壓及代謝症候群的盛行率及相關危險因子之研究20多年,有多篇論文發表並刊登於國際知名雜誌(詳見附件)。近年來在成大醫學中心成立中藥臨床試驗中心規劃並進行「六味地黃丸」及「桂附地黃丸」的雙盲臨床試驗,結果發現「六味地黃丸」有改善胰島素阻抗的作用,「桂附地黃丸」則能有效降低血糖及糖化血色素,並將成果於世界糖尿病學會研討會中發表,獲得國外熱烈的討論與迴響;此外,仍持續以動物實驗證實有效的產品或有效成份,經廠商委託研發並納入臨床試驗中,同時也進行國際的跨國(或多國)糖尿病新藥試驗,有非常豐富的臨床試驗的經驗與成果。
 
(3)近五年主要研究成果:
 
   1. Chang CJ, Yang YC, Lu FH, Lin TS, Chen JJ, Yeh TL, Wu CH, Wu JS. Altered Cardiac Autonomic Function May Precede Insulin Resistance in Metabolic Syndrome. Am J Med 2010;123(5):432-8 (SCI)
   2. Lin WY, Wu CH, Chu NF, Chang CJ. Efficacy and safety of very-low-calorie-diet in Chinese: a multi-center randomized controlled trial. Nutrition 2009; 25(11-12):1129-36. (Correspondence)
   3. Wu JS, Yang YC, Lu FH, Wu CH, Chang CJ. 2008: Population-based Study on the Prevalence and Correlates of Orthostatic Hypotension/Hypertension and Orthostatic Dizziness. Hypertens Res 2008;31:897–904 E
   4. Wu JS, Yang YC, Lu FH, Wu CH, Wang RH, Chang CJ. Population-based Study on the Prevalence and Risk Factors of Orthostatic Hypotension in Subjects with Pre-diabetes and Diabetes Mellitus. Diabetes Care. 2009;32:69-74.
   5. Wu JS, Yang YC, Lin TS, Huang YH, Chen JJ, Lu FH, Wu CH, Chang CJ. 2007: Epidemiological evidence of altered cardiac autonomic function in subjects with impaired glucose tolerance but not isolated impaired fasting glucose.J Clin Endocrinol Metab; 92: 3885–3889.
   6. Yang WS, Yang YC, Chen CL, Wu IL, Lu JY, Lu FH, Tai TY, Chang CJ. 2007: Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am J Clin Nutr; 86:509-13.
   7. Yang YC, Wu JS, Lu FH, Chang WC, Wu CH, Chang CJ. 2007: In addition to obesity and insulin resistance, microalbuminuria and diminished insulin secretion are linked with the metabolic syndrome in community-dwelling nondiabetic Taiwanese subjects. Diabetes Res Clin Pract. 76(1):102-110.
   8. Wu JS, Huang YH, Chang CJ. 2007: Preventive Health Care in the Elderly – from Guideline to Clinical Practice. Taiwan Geriatr Gerontol (in press).
   9. Chen TJ, Chang YF, Chang CS, Lu FH, Wu CH, Chang CJ. 2006: Changes of physical fitness after weight loss and the assoiated factors in obese non-diabetics. Taiwan J Fam Med. 4: 40-51.
10. Cheng JT, Huang CC, Liu IM, Tzeng TF, Chang CJ. 2006: Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats. Diabetes 55: 819-825.
 
 
 
 
 
共同主持人
吳晉祥 教授
l   中國醫藥學院醫學士
l   國立成功大學醫學工程研究所碩士
 
 
(1) 學術專長:家庭醫學、老年醫學、預防醫學
(2) 研究專長:
    長期從事糖尿病、高血壓及肥胖症的自主神經病變研究,近年來並將心臟自主神經病變以訊號處理模式分析,將論文發表於心臟、糖尿病及肥胖領域的國際知名期刊,同時吳教授也與計畫主持人共同規劃及執行中西藥有關糖尿病用藥之臨床試驗,經驗十分豐富。最近獲得台灣家庭醫學醫學會、中華民國糖尿病學會及成大醫學院最佳優秀論文獎。
 
(3)近五年主要研究成果:
1.         Chang CJ, Yang YC, Lu FH, Lin TS, Chen JJ, Yeh TL, Wu CH, Wu JS. Altered Cardiac Autonomic Function May Precede Insulin Resistance in Metabolic Syndrome. Am J Med. 2010;123(5):432-8 (SCI)
2.         Hou YW, Wu JS, Yang YC, Huang YH, Yeh TL, Lu FH, Chang CJ. The Relationship between Irritable Bowel Syndrome and Psychiatric Symptoms in Taiwanese Adult Population. Taiwan J Fam Med. 2009 (Accepted, Correspondent)
3.         Lai RH, Wu JS, Yang YC, Huang YH, Wang RH, Lu FH, Chang CJ. The Relationship between Obesity and Reflux Esophagitis in a Taiwanese Population. Taiwan J Fam Med. 2009 (Accepted)
4.         Yang LH, Wu JS, Yang YC, Sun ZJ, Huang YH, Lu FH, Chang CJ. The Relationship between Renal Function and Quality of Sleep in Subjects with Chronic Kidney Disease. Taiwan J Fam Med 2009;19:49-61.
5.         Wu JS, Yang YC, Lu FH, Wu CH, Wang RH, Chang CJ. Population-based Study on the Prevalence and Risk Factors of Orthostatic Hypotension in Subjects with Pre-diabetes and Diabetes Mellitus. Diabetes Care. 2009;32:69-74. (SCI)
6.         Chen HY, Wu JS, Hyland B, Lu XD, Chen JJ. A low noise remotely controllable wireless telemetry system for single-unit recording in rats navigating in a vertical maze. Med Biol Eng Comput. 2008;46:833-839. (SCI)
7.         Wu JS, Yang YC, Lu FH, Wu CH, Chang CJ. 2008: Population-based Study on the Prevalence and Correlates of Orthostatic Hypotension/Hypertension and Orthostatic Dizziness. Hypertens Res 2008;31:897–904. (SCI)
8.         Wu JS, Lu FH, Yang YC, Lin TS, Chen JJ, Wu CH, Huang YH, Chang CJ. Epidemiological Study on the Effect of Pre-hypertension and Family History of Hypertension on Cardiac Autonomic Function. J Am Coll Cardiol 2008;51:1896-1901. (SCI)
9.         Wu JS, Lu FH, Yang YC, Lin TS, Huang YH, Wu CH, Chen JJ, Chang CJ. Epidemiological Evidence of Altered Cardiac Autonomic Function in Overweight, but not Underweight Subjects. Int J Obes. 2008;32:788-794. (SCI)
10.     Tsai MY, Huang YH, Wu JS, Chang CJ, Yang YC. A survey on the Current State of Exercise Counseling by Diabetes Educators in Taiwan. J Evid-based Nurs 2008;4:157-166.
11.     Chen HY,Wu JS, Chen JJ, Cheng JT. Impaired Regulation Function in Cardiovascular Neurons of Nucleus Tractus Solitarii in Streptozotocin-induced Diabetic Rats. Neurosci Lett 2008;431(2):161-166. (SCI)
12.     Chiang MK, Yang YC, Wu JS, Sun ZJ, Chang YF, Lu FH. The Association between Sleep Duration and Obesity in Taiwanese Adults. Taiwan J Fam Med. 2008;18:199-209.
13.     Chao CY, Yang YC, Wu JS, Shih CC, Wu CH, Lu FH, Chang CJ. The Association Between Parental Socioeconomic Status and Metabolic Abnormalities in Young Adults - Based on a University Entrance Health Checkup. Taiwan Fam Med Res 2008;6:53-65.
14.     Chen HY, Wu JS, Chen JJ, Li CP. Wireless Telemetry System for Single-Unit Recording in Rats Navigation. Journal of the Chinese Institute of Engineers, 2007;31, 449-458. (EI)
15.     Wu JS, Huang YH, Chang CJ. Preventive Health Care in the Elderly – from Guideline to Clinical Practice. Taiwan Geriatr Gerontol 2007:2:145-163.
16.     Wu JS, Yang YC, Lin TS, Huang YH, Chen JJ, Lu FH, Wu CH, Chang CJ. Epidemiological evidence of altered cardiac autonomic function in subjects with impaired glucose tolerance but not isolated impaired fasting glucose. J Clin Endocrinol Metab 2007;92: 3885–3889. (SCI)
17.     Yang YC, Wu JS, Lu FH, Chang WC, Wu CH, Chang CJ. In addition to obesity and insulin resistance, microalbuminuria and diminished insulin secretion are linked with the metabolic syndrome in community-dwelling nondiabetic Taiwanese subjects. Diabetes Res Clin Pract 2007;76:102-110. (SCI)
18.     Lin YP, Huang YH, Yang YC, Wu JS, Chang CJ, Lu FH. Adherence to Antihypertensive Medications among the Elderly: A Community-based Survey in Tainan City, Sourthern Taiwan. Taiwan Geriatrics & Gerontology. 2007:2:176-189.
19.     Yang YC, Chen SM, Huang YH, Hu SC, Wu JS, Lu FH. The Current Status of Practicing Exercise Counseling in Teaching Staff of Family Medicine Specialty Training Hospitals in Taiwan. Taiwan Fam Med Res 2006;4:115-124.
20.     Yeh TL, Yang YK, Chiu NT, Yao WJ, Yeh SJ, Wu JS, Chuang JI, Chang SH. Correlation between Striatal Dopamine D2/D3 receptor binding and cardiovascular activity in healthy subjects. Am J Hypertens. 2006;19:964-969. (SCI)
 
 
 
 
 
 
 
 
 
 
 
楊宜青 副教授
l   國立台灣大學醫學院醫學士
l   美國哈佛大學公共衛生學院公共衛生碩士
l   成功大學醫學院醫學系家庭醫學科副教授兼代科主任
 
 
(1) 學術專長:預防保健、家庭醫學、社區醫學、運動促進、糖尿病及代謝症候群防治
(2) 研究專長及主要成果:
    長期從事糖尿病、代謝症候群、高血壓及肥胖症的社區研究,並從事運動領域的相關性研究。楊副教授與張智仁教授共同執行中西藥有關糖尿病用藥的臨床試驗,並協助行政工作的分配,以利臨床試驗計畫之進行,臨床試驗的療效評估方面,經驗十分老到。
 
(3)近五年主要研究成果:
1.         Chang CJ, Yang YC, Lu FH, Lin TS, Chen JJ, Yeh TL, Wu CH, Wu JS. Altered Cardiac Autonomic Function May Precede Insulin Resistance in Metabolic Syndrome. Am J Med 2010;123(5):432-8(SCI)(with first author equal contribution) [SCI: 5.105 (2008)14/108=13.0%]
2.         Hsuan-Jui Chang, Yin-Fan Chang, Yi-Ching Yang, Chuan-Yu Chen, Chin-Sung Chang, Chia-Wei Tu, Yu-Jang Chao, Yu-Hung Hsieh, Chih-Hsing Wu. Epidemiological survey of falls and associated risk factors in old females in an aging community. Taiwan Geriatr Gerontol 2010;5(1) :50-61.
3.         Ta-Chung Lee, How-Ran Guo, Hui-Jen Su, Yi-Ching Yang, Hsiao-Ling Chang, Kow-Tong Chen: Diseases caused by enterovirus 71 infection. Ped Infect Dis J 2009;28:904-10.
4.         Hou YW, Wu JS, Yang YC, Huang YH, Yeh TL, Lu FH, Chang CJ. The Relationship between Irritable Bowel Syndrome and Psychiatric Symptoms in Taiwanese Adult Population. Taiwan J Fam Med. 2009;19:181-91
5.         Lai RH, Wu JS, Yang YC, Huang YH, Wang RH, Lu FH, Chang CJ. The Relationship between Obesity and Reflux Esophagitis in a Taiwanese Population. Taiwan J Fam Med. 2009 (Accepted)
6.         Yang LH, Wu JS, Yang YC, Sun ZJ, Huang YH, Lu FH, Chang CJ. The Relationship between Renal Function and Quality of Sleep in Subjects with Chronic Kidney Disease. Taiwan J Fam Med 2009;19:49-61.
7.         Chi-Yuan Chao, Yi-Ching Yang,* Jin-Shang Wu, Chi-Chen Shih, Chih-Hsing Wu, Feng-Hwa Lu, Chih-Jen Chang: Association between Parental Socioeconomic Status and Metabolic Abnormalities in an University Freshmen. Taiwan Fam Med Res 2009;(accept). (*corresponding author)
8.         Hsiao-Han Lin, Winston Wen-Chien Ko, Yi-Ching Yang, Yu-Wei Chang, Kow-Tong Chen: Cost-effectiveness of influenza immunization in adult cancer patients in Taiwan. Clin Microbiol Infect 2009 (accepted) [SCI: 3.554 (2008)12/51=23.5%]
9.         Chia-Ling Wu, Yi-Ching Yang, Li-Min Huang, Kow-Tong Chen: Cost-effectiveness of childhood rotavirus vaccination in Taiwan. Vaccine 2009;27:1492-9. [SCI: 3.298 (2008)19/83=22.9%, or VETERINARY SCIENCES 1/135=0.7%]
10.     Hsing-Fang Tsai, Shu-Hui Chen, Tzung-Lieh Yeh, Chi-Chen Shih, Kao-Ching Chen, Yi-Ching Yang,* Yen-Kuang Yang: The risk factors of Internet addiction - a survey of university freshmen. Psychiatry Research 2009;167:294-9 [SCI: 2.666 (2008) 41/101=40.6%] (*corresponding author)
11.     Jin-Shang Wu, Yi-Ching Yang, Feng-Hwa Lu, Chih-Hsing Wu, Ru-Hsieh Wang, Chih-Jen Chang: Population-based Study on the Prevalence and Risk Factors of Orthostatic Hypotension in Subjects with Pre-diabetes and Diabetes Mellitus. Diabetes Care. 2009;32:69-74[SCI: 7.349(2008); 5/93=5.4%]
12.     Ming-Kai Chiang, Yi-Ching Yang,* Jin-Shang Wu, Zih-Jie Sun, Ying-Fang Chang, Feng-Hwa Lu, Chih-Jen Chang: The Association between Sleep Duration and Obesity in Taiwanese Adults. Taiwan J Fam Med 2008;18:199-209. (*corresponding author)
13.     Ming-Yan Tsai, Ying-Hsiang Huang, Jin-Shang Wu, Chih-Jen Chang, Yi-Ching Yang*: A survey on the current state of exercise counseling by diabetes educator in Taiwan. Evidence Based Nursing 2008;4(2):157-166. (*corresponding author)
14.     Jin-Shang Wu, Yi-Ching Yang, Feng Hwa Lu, Chih-Hsing Wu, Chih-Jen Chang: Population-based study on the prevalence and correlates of orthostatic hypotension/hypertension and orthostatic dizziness. Hypertens Res 2008;31:897-904. [SCI: 3.146(2008); 18/56=32.1%]
15.     Jin-Shang Wu, Feng-Hwa Lu, Yi-Ching Yang, Thy-Sheng Lin, Ying-Hsiang Huang, Chih-Hsing Wu, Jia-Jin Chen, Chih-Jen Chang: Epidemiological Study on the Effect of Pre-hypertension and Family History of Hypertension on Cardiac Autonomic Function. J Am Coll Cardiol 2008;51:1896-901. [SCI: 11.438 (2008); Cardiac & Cardiovascular systems 3/77=3.8%]
16.     Jin-Shang Wu, Feng Hwa Lu, Yi-Ching Yang, Thy-Sheng Lin, Ying-Hsiang Huang, Chih-Hsing Wu, Jia-Jin Chen, Chih-Jen Chang: Epidemiological Evidence of Altered Cardiac Autonomic Function in Overweight, but not Underweight Subjects. Int J Obes 2008;32:788-94 [SCI:3.640(2008); NUTRITION & DIETETICS: 9/59=15.3%]
17.     Yu-Pei Lin, Ying-Hsiang Huang, Yi-Ching Yang, Jin-Shang Wu, Chih-Jen Chang, Feng-Hwa Lu: Adherence to antihypertensive medications among the elderly: a community-based survey in Tainan City, Southern Taiwan. Taiwan Geriatrics Gerontology 2007;2:176-189.
18.     Chuan Yu Chen, Yi-Ching Yang*: Improve the quality of medical care in an aged and doctor-deficiency rural area: the Tianliao model mobile healthcare program. Taiwan Geriatrics Gerontology 2007;2:209-23. (*corresponding author)
19.     Cheng-Yu Lin, Yi-Ching Yang; Yueliang Leon Guo, Chih-Hsing Wu, Chih-Jen Chang, Jiunn-Liang Wu: Prevalence of hearing impairment in an adult population in southern Taiwan. Int J Audiol 2007;46:732-37. [SCI: 1.201(2008); OTORHINOLARYNGOLOGY: 15/31=48.3%]
20.     Jin-Shang Wu, Yi-Ching Yang, Thy-Sheng Lin, Ying-Hsiang Huang, Jia-Jin Chen, Feng-Hwa Lu, Chih-Hsing Wu, and Chih-Jen Chang: Epidemiological evidence of altered cardiac autonomic function in subjects with impaired glucose tolerance but not isolated impaired fasting glucose. J Clin Endocrinol Metab 2007;92:3885-9. [SCI:6.325(2008);ENDOCRINOLOGY & METABOLISM: 11/93=11.8%]
21.     Wei-Shiung Yang, Yi-Ching Yang, Chi-Ling Chen, I-Ling Wu, Jin-Ying Lu, Feng-Hwa Lu, Tong-Yuan Tai, and Chih-Jen Chang: Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am J Clin Nutr 2007;86:509-13. [SCI:6.740(2008); NUTRITION & DIETETICS: 3/59=5.0%]
22.     Yi-Ching Yang, Jin-Shang Wu, Feng-Hwa Lu, Wan-Chi Chang, Chih-Hsing Wu, Chih-Jen Chang: In addition to obesity and insulin resistance, microalbuminuria and diminished insulin secretion are linked with the metabolic syndrome in community-dwelling nondiabetic Taiwanese subjects. Diabetes Res Clin Pract 2007;76(1):102-10.[SCI:1.888(2008); ENDOCRINOLOGY & METABOLISM: 74/93=79.5%]
23.     Yi-Ching Yang, Shu-Mei Chen, Ying-Hsiang Huang, Shu-Chen Hu, Jin-Shang Wu, Feng-Hwa Lu: The Current Status of Practicing Exercise Counseling in Teaching Staff of Family Medicine Specialty Training Hospitals in Taiwan. Taiwan Fam Med Res 2006;4:115-124.
24.     Kuan-Ju Chen, Lily Yeh, Yi-Ching Yang, Feng-Hwa Lu, Wen-Ling Wang: Factors Influencing Physical Activity in previous year among University Freshmen. Chang Gung Nursing 2006;17:408-17.
 
 
 
  
劉崇喜 教授
l   高雄醫學院藥學博士
l   現任大仁科技大學藥學系教授
l   行政院農業委員會屏東農業生物技術園區籌備處審查委員。
 
 
 
(1) 學術專長:中藥炮製、中藥藥物開發、健保食品開發。
(2) 研究專長:
    致力於中藥材炮製之相關研究,陸續完成有關於半夏、附子、厚朴、五味子、何首烏及當歸等中藥炮製計畫及市售參茸藥酒長期服用之下毒性的評估等等。冀由建立炮製研究規範,以切實管控原料規格,進而促進台灣中藥飲片品質之均一性,輔以推動中藥GMP飲片炮製工廠之成立,讓民眾獲得安全、均一及有效之中藥材產品。
(3)近五年主要研究成果:
1.     Cheng YB, Chang MT, Lo YW, Ho CJ, Kuo YC, Chien CT, Chen SY, Liou SS, Kuo YH, Shen YC, Oxygenated Lignans from the Fruits of Schisandra arisanensis. Journal of natural products, 2009 Aug 12.
2.     Liu IM, Tzeng TF, Liou SS, Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity.Phytother Res, 2009 Jul 16.
3.     Liu IM, Tzeng TF, Liou SS, Chang CJ. The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription. Journal of ethnopharmacology, 124(2):211-8(2009).
4.     Liu IM, Tzeng TF, Liou SS. A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis, Ameliorates Insulin Resistance Induced by A High-Fructose Diet in Rats. Evidence-based complementary and alternative medicine, 2009 Feb 20.
5.     Shen YC, Lin YC, Cheng YB, Chiang MY, Liou SS, Khalil AT, Dibenzocyclooctadiene lignans from Kadsura philippinensis. Phytochemistry, 70(1),114-120(2009).
6.     Shen YC, Lin YC, Chang CJ, Lan TW, Liou SS, Chien CT, Liaw CC and Khalil AT, New Oxygenated Lignans from Kadsura philippinensis. Helvetica Chimica Acta, 91(3), 483-494(2008).
7.     Liu IM, Yu WJ, Liou SS, Tzeng TF, Tsai IH, Cheng AT, Role of Alcohol in the induction of Hepatic injury by Chronic Consumption of Medicated Wine. Journal of Food and Drug Analysis, 15(4), 466-471 (2007).
8.     Liu IM, Tzeng TF, Liou SS, Lan TW, Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sciences, 81(21-22), 1479–1488 (2007).
9.     Liu IM, Tzeng TF, Liou SS, Lan TW, Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Medica, 73(10), 1054-1060 (2007).
10. Shen YC, Cheng YB, Lan TW, Liaw CC, Liou SS, Kuo YH and Khalil AT, Kadsuphilols A-H,Oxygenated Lignans from Kadsura philippinensis. Journal of Natural Products, 70, 1139-1145 (2007).
11. Shen YC, Liaw CC, Cheng YB, Ahmed AF, Lai MC, Liou SS, WU TS, Kuo YH and Lin YC, C18 Dibenzocyclooctadiene Lignans from Kadsura philippinensis. Journal of Natural Products, 69(6), 963-966 (2006).
12. Liou SS, Liu IM, Lai MC, The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 106(2), 256-262 (2006).
13. Liu IM, Liou SS, Cheng JT, Mediation of beta-endorphin by Myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 104(1-2), 199-206 (2006).
 
 
 
 
 
劉怡旻 教授
l   國立成功大學基礎醫學研究所博士
l   現任大仁科技大學教授
l   大仁科技大學中草藥科技研究中心主任。
 
 
 
(1) 學術專長:藥理學、中醫藥理學、藥物治療學
(2) 研究專長及主要成果:
    長期投入中草藥的研究,針對傳統方劑作用機制以及個別藥材進行藥理解析,以期能益助中草藥於臨床治療或改善代謝性症候群的應用;並積極致力於中藥新療效的開發,如探討傳統中藥方劑「五苓散」改善糖尿病腎臟病變之藥效與針對「當歸補血湯」是否具有改善胰島素抗性的作用進行評估。同時接受屏東農業生物科技園區進駐廠商委託進行產品功效評估與研發,包括「紅麴滴丸製劑之研發」、鯊魚軟骨粉末應用於糖尿病傷口癒合的評估」與進行「台灣產金銀花促進傷口癒合製劑之研發」等,有非常豐富的產學合作經驗。
(3)近五年主要研究成果:
1.         Liu IM, Tzeng TF, Liou SS, Chang CJ. (2011) Angelica acutiloba Root Attenuates Insulin Resistance Induced by High-Fructose Diet in Rats. Phytotherapy research in press
2.         Liu IM, Tzeng TF, Liou SS. (2010) Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity. Phytotherapy research 24(2):233-239.
3.         Tzeng TF, Liou SS, Liu IM. (2010) Myricetin ameliorates defective post-receptor insulin signaling via b-endorphin signaling in the skeletal muscles of fructose-fed rats. Evidence-Based Complementary and Alternative Medicine in press 
4.         Yang TT, Liu IM, Wu HT, Cheng JT (2009) Mediation of protein kinase C zeta in mu-opioid receptor activation for increase of glucose uptake into cultured myoblast C2C12 cells. Neuroscience Letters, 465(2):177-180. 
5.         Liu IM, Tzeng TF, Liou SS, Chang CJ (2009) The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription. Journal of Ethnopharmacology, 124(2): 211-218.
6.         Liu IM, Tzeng TF, Liou SS (2009) A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis, Ameliorates Insulin Resistance Induced by A High-Fructose Diet in Rats. Evidence-Based Complementary and Alternative Medicine in press
7.         Liu IM, Tzeng TF, Liou SS, Chang CJ (2009) The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription. Journal of Ethnopharmacology, 124(2): 211-218.
8.         Liu IM, Cheng JT (2008) Mediation of endogenous β-endorphin in the plasma glucose-lowering action of herbal products observed in type 1-like diabetic rats. Evidence-Based Complementary and Alternative Medicine in press
9.         Niu HS, Hsu FL, Liu IM (2008) Role of sympathetic tone in the loss of syringin-induced plasma glucose lowering action in conscious Wistar rats. Neuroscience Letter, 445(1):113-116.
10.     Liu IM, Chang CK, Juang SW, Kou DH, Tong YC, Cheng KC, Cheng JT (2008) Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. International Journal of Experimental Pathology, 89(4):292-300.
11.     Ko WC, Liu IM, Chung HH, Cheng JT (2008) Activation of I(2)-imidazoline receptors may ameliorate insulin resistance in fructose-rich chow-fed rats. Neuroscience Letter, 448(1): 90-93.
12.     Lee LM, Chang CK, Cheng KC, Kou DH, Liu IM, Cheng JT (2008) Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats. Neuroscience Letter, 441(2):201-204.
13.     Liu KY, Wu YC, Liu IM, Yu WC, Cheng JT (2008) Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats. Neuroscience Letter, 434(2):195-199.
14.     Niu HS, Liu IM, Cheng JT, Lin CL, Hsu FL (2008) Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats. Planta Medica, 74(2): 109-113.
15.     Liu IM, Tzeng TF, Liou SS, Lan TW (2007) Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Medica, 73(10):1054-1060.
16.     Hsu JH, Wu YC, Liu IM, Cheng JT (2007) Dioscorea as the principal herb of Die-Huang-Wan, a widely used herbal mixture in China, for improvement of insulin resistance in fructose-rich chow-fed rats. Journal of Ethnopharmacology, 112(3):577-584.
17.     Lee WK, Kao ST, Liu IM, Cheng JT (2007) Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. Hormone and Metabolic Research, 39(5):347-354.
18.     Lo YT, Tzeng TF, Liu IM (2007) Role of tumor suppressor PTEN in tumor necrosis factor alpha-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells. Hormone and Metabolic Research, 39(3):173-178.
19.     Tzeng TF, Lo CY, Cheng JT, Liu IM (2007) Activation of micro-opioid receptors improves insulin sensitivity in obese Zucker rats. Life Science, 80(16):1508-1516.
20.     Chan P, Liu IM, Tzeng TF, Yang TL, Cheng JT (2007) Mechanism for blockade of angiotensin subtype 1 receptors to lower plasma glucose in streptozotocin-induced diabetic rats. Diabetes, Obesity & Metabolism, 9(1):39-49.
21.     Su CF, Cheng JT, Liu IM (2007) Increase of acetylcholine release by Panax ginseng root enhances insulin secretion in Wistar rats. Neuroscience Letters, 412(2):101-114.
22.     Huang CJ, Liu IM, Cheng JT (2007) Increase of peroxisome roliferator-activated receptor delta gene expression in the lungs of streptozotocin-induced diabetic rats. Pulmonary Pharmacology & Therapeutics, 20(1):69-74.
23.     Lee WK, Kao ST, Liu IM, Cheng JT (2007) Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. Hormone and Metabolic Research, 39(5):347-354.
24.     Chen CC, Liu IM (2006) Release of acetylcholine by Hon-Chi to raise insulin secretion in Wistar rats. Neuroscience Letters, 404(1-2):117-121.
25.     JH, Wu YC, Liu IM, Cheng JT (2006) Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis. Neuroscience Letters, 404(1-2):112-116.
26.     Chang SP, Chen YH, Chang WC, Liu IM, Cheng JT (2006) Increase of adiponectin receptor gene expression by physical exercise in soleus muscle of obese Zucker rats. European Journal of Applied Physiology, 97(2):189-195.
27.     Zhang YW, Xie D, Xia B, Zhen RT, Liu IM, Cheng JT (2006) Suppression of transforming growth factor-beta1 gene expression by Danggui buxue tang, a traditional Chinese herbal preparation, in retarding the progress of renal damage in streptozotocin-induced diabetic rats. Hormone and Metabolic Research, 38(2):82-88.
28.     Chen CC, Liu IM, Cheng JT (2006) Improvement of insulin resistance by miracle fruit (Synsepalum dulcificum) in fructose-rich chow-fed rats. Phytotherapy research, 20(11):987-992.
29.     Cheng JT, Huang CC, Liu IM, Tzeng TF, Chang CJ (2006) Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats. Diabetes, 55(3):819-825.
30.     Chang SP, Chen YH, Chang WC, Liu IM, Cheng JT (2006) Merit of physical exercise to reverse the higher gene expression of hepatic phosphoenolpyruvate carboxykinase in obese Zucker rats. Life Science, 79(3):240-246.
31.     Ko WC, Liu TP, Cheng JT, Tzeng TF, Liu IM (2006) Effect of opioid mu-receptors activation on insulin signals damaged by tumor necrosis factor alpha in myoblast C2C12 cells. Neuroscience Letters, 397(3):274-278.
 
 
 
 
 
 
 
 
 
 
 
協同主持人
蔡金川 教授
(1) 學經歷: 中國醫藥大學醫學博士。現任義守大學學士後中醫系系主任,義
大醫院中醫部部長
(2) 學術專長: 一般內科、肝膽疾病、睡眠障礙、代謝症候群。
(3) 研究專長及主要成果:致力於研究中藥實證化及中草藥改善癌症患者化學 
治療副作用之臨床實證研究。
 
l      何婉清 教授
(1)學經歷:美國夏威夷大學博士,現任大仁科技大學生物科技系教授。
(2)學術專長:植物病害生物防治、綜合防治、土壤傳播病害、微生物學、真
菌學、生態學、生物農藥的開發與利用
(3)研究專長及主要成果:
    長期致力於土壤傳播病害微生物學、真菌學與生態學的研究,對於生物農藥的開發與利用植物病害生物防治與綜合防治均有顯著成果與豐富經驗。對於原住民保留地高經濟作物發展潛力之研究著墨甚多,期能有助於原住民充分及合理利用土地資源,同時能落實兼顧水土保持與環境保護之理念,更因為高經濟作物之特殊環境需求,而能建立地區化生產專業區,提高原住民之生產技術與收益,並提升原住民鄉整體的環境與生活品質。
 
l      陳柏熹 助理教授
(1) 學經歷: 高雄醫學大學醫學士,成功大學基礎醫學研究所博士。現任國立
成大醫院斗六分院精神暨長期照護部主任。
(2) 學術專長:神經影像、精神藥理及神經免疫學
(3) 研究專長及主要成果:
    從事正常人及精神疾病患者腦部影像學方面的研究已有多年,同時其研究成果發表刊登於國際知名雜誌(詳見附件),其研究對象包括正常健康人、吸菸者、肥胖者及精神病患,同時探討藥物對腦部影像或代謝異常的影響。所以此次計畫陳助理教授可以協助動物實驗模式之建立及臨床試驗正常人及糖尿病人的腦部影像學及生理功能評估。
 
l      歐弘毅 助理教授
(1) 學經歷: 台北醫學大學醫學士,成大臨床醫學研究所博士,現任成大醫院 
            臨床助理教授兼主治醫師
(2) 學術專長:糖尿病、肥胖症、骨質疏鬆、甲狀腺疾病
(3) 研究專長及主要成果:
    從事代謝疾病之相關研究,包含糖尿病、肥胖症等,同時亦致力於脂肪肝形成機轉之相關研究。
 
l      朱世德 副教授
(1) 學經歷: 日本星藥科大學藥學博士,現任大仁科技大學藥學系副教授
(2) 學術專長:有機合成化學,微生物與免疫學,生物科技
(3) 研究專長及主要成果:
    長期從事微生物對藥物之耐受性分析與生理活性物質之化學合成。目前輔導進駐屏東農業生物科技園區之廠商針對機能性米食、米製品、米飲品系列及具高功能價值(醫療保健,美容…等)的米食進行研發。
 
l      翁順祥 副教授
(1) 學經歷: 國立台灣大學農業化學博士,現任大仁科技大學食品科技系(所)副教授、大仁科技大學校務會議委員、行政院公共工程學者專家委員、美和技術學院董事。
(2) 學術專長:食品化學、發酵技術。
(3) 研究專長及主要成果:
    專精食品化學,發酵技術,從事健康保健食品安全管制,台灣栽培種當歸、刺五加產品產業化推廣,對於中草藥、蔬果作物開發健康保健食品,有豐富的經驗與成果。
 
l      洪堂耀 助理教授
(1) 學經歷: 國立中興大學博士,現任大仁科技大學助理教授。
(2) 學術專長:抗真菌蛋白質的開發、纖維素分解酵素生產菌株的篩選、鑑定
              與基因選殖
(3) 研究專長及主要成果:
    從事抗真菌蛋白質的開發與纖維素分解酵素生產菌株的篩選、鑑定與基因選殖。於中草藥的基原鑑定、健康食品功能性與安全性的評估亦有豐富的經驗與成果。目前經廠商委託進行水解酵母細胞壁套組試劑之開發研究。
 
l      許仁豪 助理教授
(1) 學經歷: 高雄醫學大學天然藥物研究所博士,大仁科技大學助理教授,義大醫院中醫針灸科主任
(2) 學術專長:針灸治療
(3) 研究專長及主要成果:
    主要研究中風(腦損傷)後遺症輔助治療、各種運動傷害、筋骨肌肉酸痛、五十肩、腰背肌肉關節酸痛、坐骨神經痛、退化性關節炎、外傷後遺症、癌症疼痛、中醫體重控制、體質調理。
 
最後更新日期   
2011-09-30